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Babu Sudhamalla Assistant Professor |
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Research Interest:
Exploring the mechanism and biological functions of epigenetic ‘readers’ and ‘erasers’ by using genetically encoded unnatural amino acids. My research takes a multidisciplinary approach that involve protein engineering, biochemistry, molecular biology, proteomics, mammalian tissue culture system, homology modelling, docking and molecular dynamics simulations to interrogate cellular machineries towards molecular understanding of epigenetic mechanisms in human health and disease.
Academic Background:
- Ph.D. (Biochemistry), School of Chemistry, University of Hyderabad, 2014
- M.Tech. (Bioinformatics), Department of Biotechnology, University of Hyderabad, 2009
- B.Tech. (Biotechnology), Jawaharlal Nehru Technological University, Hyderabad, 2006
Positions:
- Assistant Professor-Indian Institute of Science Education and Research-Kolkata (2018-present)
- Post-Doctoral Researcher-University of Pittsburgh, Pittsburgh, PA, USA (2014-2018)
Awards and Honors:
- 2012-2014: DBT Senior Research Fellow
- 2010-2012: DBT Junior Research Fellow
- 2009-DBT-Junior Research Fellowship (Qualified in Category-A-Top 100 fellowships)
Selected Publications:
- Sudhamalla B, Wang S, Snyder V, Kavoosi S, Arora S, Islam K. (2018) Complementary Steric Engineering at the Protein-Ligand Interface for Analogue-Sensitive TET Oxygenases. J. Am. Chem. Soc. 140(32)10263-10269.
- Sudhamalla B, Dey D, Breski M, Islam K. (2017) A rapid mass spectrometric method for the measurement of catalytic activity of ten-eleven translocation enzymes. Anal Biochem. 534:28-35.
- Sudhamalla B, Dey D, Breski M, Nguyen T, Islam K. (2017) Site-specific azide-acetyllysine photochemistry on epigenetic readers for interactome profiling. Chem Sci. 8(6) 4250-4256.
- Gabriella T. Perell, Neeraj K. Mishra, Sudhamalla B, Peter D. Ycas, Islam K, William C.K. Pomerantz. (2017) Specific Acetylation Patterns of H2A.Z Form Transient Interactions with the BPTF Bromodomain. Biochemistry. 56(35) 4607-4615.
- Breski M, Dey D, Obringer S, Sudhamalla B, Islam K. (2016) Engineering Biological C-H Functionalization Leads to Allele-Specific Regulation of Histone Demethylases. J. Am. Chem. Soc. 138 (41) 13505–13508.