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Arnab Gupta Assistant Professor |
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Research Interest:
- For all living organisms, copper is essential but in excess, is extremely toxic. Wilson disease and Menkes disease are two major disorders of copper homeostasis. My laboratory is interested to understand the mechanism of copper entry and exit into mammalian cells. Towards that goal we are trying to understand how the mammalian copper importer channel CTR1 and copper exporting pumps ATP7A and ATP7A functions and is regulated by other proteins
Academic Background:
- PhD (2001-2006) in Science from Indian Institute of Chemical Biology (Jadavpur University); Degree awarded in 2007
- Master of Science (2000) in Zoology from University of Calcutta
- Bachelor of Science (1998) in Zoology (hons) from University of Calcutta
Positions:
- Ramanujan Fellow and Faculty, SN Pradhan Centre for Neurosciences, University of Calcutta (2015-2017)
- Research Associate, Dept. of Cell Biology, School of Medicine, Johns Hopkins University, MD (2012-2015)
- Post-doctoral fellow, Dept. of Physiology, School of Medicine, Johns Hopkins University, MD, USA (and formerly at Oregon Health & Science University, Portland, OR). (2007- 2011)
- Research Fellow (PhD candidate) PhD degree from Indian Institute of Chemical Biology (IICB), Jadavpur University, India.
Awards and Honors:
- Wellcome Trust-DBT India Alliance Intermediate Fellowship (2016)
- Ramanujan Fellowship Department of Science & Technology, Govt. of India (2015)
- Early Career research Award Department of Science & Technology, Govt. of India(2016)
- Travel award Indian Society of Human Genetics (2014)
- NL Tartar Fellowship (Oregon Health Sciences University 2008)
- International Travel grant Council of Scientific & Industrial Research 2005
Selected Publications:
- Arnab Gupta^, Michael J. Schell, Ashima Bhattacharjee, Svetlana Lutsenko, Ann L. Hubbard. Myosin Vb mediates copper export in polarized hepatocytes. Journal of Cell Sciences. 2016. 129: 1179- 1189 (^corresponding author)
- Lita Braiterman, Arnab Gupta, Raghothama Chaerkady, Robert N. Cole and Ann Hubbard Communication between the N- and C-termini is required for Cu-stimulated Ser/Thr phosphorylation of Cu-(I)ATPase (ATP7B). Journal of Biological Chemistry. 2015. 290(14):8803-19
- Nesrin M. Hasan*, Arnab Gupta*, Elena Polishchuk, Corey H. Yu, Roman Polishchuk, Oleg Y. Dmitriev, and Svetlana Lutsenko. Molecular events initiating exit of a copper transporting ATPase ATP7B from the Trans-Golgi network. Journal of Biological Chemistry. 2012. 287(43):36041-50 (*equal contributors)
- Arnab Gupta# and Svetlana Lutsenko. Evolution of Copper transporting ATPases in eukaryotic organisms. Current Genomics. 2011;13: 124-133 (#corresponding author)
- Arnab Gupta*, Ashima Bhattacharjee*, Oleg Y. Dmitriev, Sergiy Nokhrin, Lelita Braiterman, Ann Hubbard, Svetlana Lutsenko. Cellular copper levels determine the phenotype of the Arg875 variant of ATP7B/Wilson disease protein. Proceedings of the National Academy of Sciences USA. 2011; 108:5390-5.